BUTTPARK 14650-45

BUTTPARK 14650-45 - Names and Identifiers

Name	2-bromo-1-(4-morpholinophenyl)-1-ethanone
Synonyms	BUTTPARK 14650-45 2-Bromo-4'-morpholinoacetophenone 4-(Morpholin-4-yl)phenacyl bromide 2-Bromo-1-(4-morpholinophenyl)ethanone 2-BROMO-1-(4-MORPHOLINOPHENYL)-1-ETHANONE 2-Bromo-1-(4-morpholinophenyl)-1-ethanone 2-bromo-1-(4-morpholinophenyl)-1-ethanone 2-Bromo-1-(4-morpholin-4-ylphenyl)ethanone 2-Bromo-4'-(morpholin-4-yl)acetophenone, 2-Bromo-1-[(4-morpholin-4-yl)phenyl]ethan-1-one
CAS	210832-85-2
InChI	InChI=1/C12H14BrNO2/c13-9-12(15)10-1-3-11(4-2-10)14-5-7-16-8-6-14/h1-4H,5-9H2

BUTTPARK 14650-45 - Physico-chemical Properties

Molecular Formula	C12H14BrNO2
Molar Mass	284.15
Density	1.439g/cm³
Melting Point	112 °C
Boling Point	418.8°C at 760 mmHg
Flash Point	207.1°C
Vapor Presure	3.18E-07mmHg at 25°C
Storage Condition	Keep Cold
Sensitive	Lachrymatory
Refractive Index	1.581
Physical and Chemical Properties	Melting point 112°C storage conditions Keep Cold sensitive Lachrymatory

BUTTPARK 14650-45 - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Hazard Note	Corrosive/Lachrymatory/Keep Cold

BUTTPARK 14650-45 - Reference Information

preparation

1) preparation of intermediate 4-morpholine phenyl ethyl ketone
take 50g of 4-fluoroacetophenone, dissolve it in 350mL of dimethyl sulfoxide (DMSO) (about 7-8 times the mass-volume ratio), stir it evenly, and it is a colorless solution at this time. 78.8g(0.9mol) of morphine was slowly added at normal temperature, after dropping, the temperature was raised to 120 ℃ for reflux. The solution gradually turns pale yellow. The reaction was 3~4h, and the reaction endpoint was monitored by TLC, and the reaction was complete. After the reaction is over, let it stand to room temperature. Slowly pour the reaction liquid into a large amount of ice water, stir, and yellow solids are precipitated. Filter by suction, collect filter cake, wash twice with water, and dry to obtain 63g of yellow solid (yield 85%).
2) preparation of intermediate 2,2-dibromo -1-(4-morpholine phenyl) ethyl ketone
30g(0.15mol) of 4-morpholine phenyl ethyl ketone and 210mL (about 7-8 times the mass volume ratio) of concentrated sulfuric acid were added into a 500mL three-neck bottle equipped with mechanical stirring and thermometer, and stirred to dissolve it. The reaction solution was cooled to 0 ℃, bromine 7.8mL was slowly dripped at this temperature, and the temperature was controlled at 0 ℃. Drop, react at room temperature. The reaction was about 6h, and TLC was used to monitor whether the reaction was complete. Pour the reaction liquid into a large amount of ice water, and yellow-green solids are precipitated and stirred. After the ice is dissolved, filter and wash with water until neutral. The filter cake was collected and dried to obtain 47g of yellow-green solid with 88% yield.

Last Update：2024-04-09 20:52:54